Creatine Kinase Isoenzyme, MB

Code

1555

Principle

CK-MB is an enzyme that represents a significant fraction of the creatine kinase present in myocardial tissue. CK-MB is also present in a variety of other tissues, although at much lower levels. The appearance of CK-MB in serum, in the absence of major muscle trauma, may be indicative of cardiac damage and thus, myocardial infarction (MI).

Preanalytical

1 mL Serum Refrigerated

Turn Around Time

1 day

Methodology

Chemiluminescent immunoassay (CLIA)

Limitations

CK-MB levels can be increased in any conditions resulting in myocardial cell damage. For MI diagnostic purposes, the  CK-MB results should be used in conjunction with other information such as cardiac marker results (e.g., troponin-I and/or myoglobin), ECG, clinical observations and symptoms, etc.

Patients who have been regularly exposed to animals or have received immunotherapy or diagnostic procedures utilizing immunoglobulins or immunoglobulin fragments may produce antibodies, e.g. HAMA, that interfere with immunoassays.