Cyclosporine

Code

1630

Principle

Cyclosporine is a cyclic undecapeptide of fungal origin and a potent immunosuppressant. It is used as a primary agent during immunosuppressive therapy for solid organ transplants.

Preanalytical

3 mL EDTA Whole Blood Refrigerated

Turn Around Time

1 day

Methodology

Chemiluminescent microparticle immunoassay (CMIA)

Limitations

Heterophilic antibodies in human serum can react with immunoglobulins, interfering with in vitro immunoassays. Patients routinely exposed to animals or to animal serum products can be prone to this immunoglobulins interference, and anomalous values may be observed. Additional information may be required for diagnosis. Specimens from patients who have received preparations of mouse monoclonal antibodies for diagnosis or therapy may contain human anti-mouse antibodies (HAMA). Specimens containing HAMA may produce anomalous values when tested.