Dehydroepiandrosterone-Sulfate (DHEA-S)

Code

1715

Principle

Dehydroepiandrosterone sulfate (DHEA-S) is a steriod synthesized primarily by the adrenal gland. In those tissues containing sulfatase activity, DHEA-S can be converted to free steroid DHEA. Subsequently, DHEA and/or DHEA-S may be partially metabolized into active androgens and estrogens. DHEA-S may be used in the differential diagnosis of Cushing’s syndrome.DHEA-S may also be used to evaluate adrenocortical diseases, such as congenital adrenal hyperplasia and adrenal tumors.

Preanalytical

1 mL Serum Refrigerated

Turn Around Time

1 day

Methodology

Chemiluminescent immunoassay (CLIA)

Limitations

Patients who have been regularly exposed to animals or have received immunotherapy or diagnostic procedures utilizing immunoglobulins or immunoglobulin fragments may produce antibodies, e.g. HAMA, that interfere with immunoassays.