Digoxin

Code

1790

Principle

Digoxin is a potent cardiac glycoside prescribed for the treatment of patients suffering from congestive heart failure or from some types cardiac arrhythmias. Monitoring of serum digoxin levels is performed because the drug has a low therapeutic ratio (a small difference between therapeutic and tissue toxic levels) and because the symptoms of drug overdose may resemble the original condition for which the drug was prescribed.

Preanalytical

1 mL Serum Refrigerated

Turn Around Time

1 day

Methodology

Chemiluminescent microparticle immunoassay (CMIA)

Limitations

 Specimens from patients who have received preparations of mouse monoclonal antibodies for diagnosis or therapy may contain human anti-mouse antibodies (HAMA). Specimens containing HAMA may produce anomalous values when tested.

Digoxin values for specimens from patients who have received DIGIBIND or DIGIFAB therapy may be impacted.