Insulin, Fasting

Code

3390

Principle

Insulin is a hormone secreted by the beta cells of the pancreas. Insulin regulates the uptake and utilization of glucose, and is also involved in the regulation of protein synthesis and triglyceride storage.1,2,3 An increase in the amount of glucose in circulation stimulates insulin secretion. Insulin in turn stimulates the uptake of glucose into the tissues and inhibits the breakdown of glycogen in the liver. As the glucose level comes back to baseline so does insulin.

Preanalytical

1 mL Serum Refrigerated

Turn Around Time

1 day

Methodology

Chemiluminescent immunoassay (CLIA)

Limitations

Patients who have been regularly exposed to animals or have received immunotherapy or diagnostic procedures utilizing immunoglobulins or immunoglobulin fragments may produce antibodies, e.g. HAMA, that interfere with immunoassays.

Patients on insulin therapy are prone to the development of anti-insulin antibodies. These antibodies may interfere with the assay.

All results should be interpreted in light of the total clinical presentation of the patient, including: symptoms, clinical history, data from additional tests and other appropriate information.