Vitamin B12 (Cyanocobalamine)

Code

6460

Principle

Vitamin B12 is a coenzyme that is involved in two very important metabolic functions vital to normal cell growth and DNA synthesis: 1) the synthesis of methionine, and 2) the conversion of methylmalonyl CoA to succinyl CoA. Deficiency of this vitamin can lead to megaloblastic anemia and ultimately to severe neurological problems.

Preanalytical

1 mL Serum Refrigerated

Turn Around Time

1 day

Methodology

Chemiluminescent immunoassay (CLIA)

Limitations

Patients who have been regularly exposed to animals or have received immunotherapy or diagnostic procedures utilizing immunoglobulins or immunoglobulin fragments may produce antibodies, e.g. HAMA, that interfere with immunoassays.